Current Issue : January - March Volume : 2014 Issue Number : 1 Articles : 4 Articles
Identification and characterization of an excipient from natural sources is an alternative approach in formulation development. The present study was carried out to extract starch from Lentil and to evaluate its binding property in tablets using ketoprofen as model drug. Starch extraction was carried out using acetone to precipitate starch. Formulations of ketoprofen tablets were prepared using the extracted starch as binder in varying proportions. The tablets were prepared by wet granulation technique. Pre compression and post compression parameters were performed for all the prepared formulation batches. The prepared tablets showed good friability and hardness which are within the limits. The drug content of the formulations was found to be in the range of 94 to 96%. Formulation F2 showed better results as compared to other formulations in terms of disintegration test and in-vitro dissolution studies. The results obtained in this study confirmed that starch isolated from Lentil, a natural source is having an excellent binding property which could be employed as an alternate excipient in the routine manufacturing of tablet dosage form....
Rizatriptan benzoate, a selective 5-hydroxytryptamine receptor agonist, indicated for the acute treatment of migraine. The main motive of the present study was to develop rapid disintegrating tablets (RDT) of rizatriptan benzoate and study the effect of super disintegrants (sodium starch glycolate, croscarmellose sodium, crospovidone) on disintegration time and enhancement of dissolution. Direct compression technique was employed for the preparation of tablets as all the ingredients of the study are free flowing. The effect of Mannitol and spray dried lactose (SDL) was studied with respect to the different superdisintegrants, different ratios of SDL: mannitol used in the study are 1:1, 2:3, 3:2, 1:4 and 4:1. All the batches were evaluated for weight variation, friability, hardness, thickness, disintegration time, water absorption ratio, wetting time and in-vitro dissolution studies....
Thiolated chitosan (Thio-CS) is a well-established pharmaceutical excipient for drug delivery. However, its use as a scaffold for\r\nbone formation has not been investigated. The aim of this study was to evaluate the potential of Thio-CS in bone morphogenetic\r\nprotein-2 (BMP-2) delivery and bone formation. In vitro study showed that BMP-2 interacted with the Thio-CS and did not affect\r\nthe swelling behavior. The release kinetics of BMP-2 fromthe Thio-CS was slightly delayed (70%) within 7 days compared with that\r\nfromcollagen gel (Col-gel, 85%), which is widely used in BMP-2 delivery.The BMP-2 released fromThio-CS increased osteoblastic\r\ncell differentiation but did not show any cytotoxicity until 21 days. Analysis of the in vivo ectopic bone formation at 4 weeks of\r\nposttransplantation showed that use of Thio-CS for BMP-2 delivery induced more bone formation to a greater extent (1.8 fold)\r\nthan that of Col-gel. However, bone mineral density in both bones was equivalent, regardless of Thio-CS or Col-gel carrier. Taken\r\ntogether, Thio-CS system might be useful for delivering osteogenic protein BMP-2 and present a promising bone regeneration\r\nstrategy....
The use of naturally occurring biocompatible materials has been the focus of recent research activity in the design of dosage forms\r\nfor immediate and controlled release formulations. Grewia gum is an intracellular gum obtained by extraction from the inner\r\nstem bark of the shrub Grewia mollis (Malvaceae). It grows abundantly (wild or cultivated) in the middle belt region of Nigeria,\r\nand the mucilage has been used by indigenes of this belt as thickener in soups. Grewia gum has been investigated for potential\r\napplications in pharmaceutical dosage forms.The industrial extrapolation of the applications of the gum has, however, been slowed\r\nby the limited structural, toxicological, and stability data available on the gum. This paper highlights ethnobotanical uses of G.\r\nmollis shrub and discusses the structural features, functional properties, and applications of grewia gum with emphases on its\r\npharmaceutical potentials....
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